Role of JAK3 in the Pathogenesis of Oxidative Stress-Induced Kidney Fibrosis

The Janus kinase (JAK) tyrosine kinase family and JAK/STAT signal transduction pathway may act in kidney fibrogenesis. JAK3 expression was investigated in in vitro and in vivo models of kidney fibrosis involving oxidative stress. There was a marked down-regulation of JAK3 mRNA in rat kidney tubular...

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Bibliographic Details
Main Authors: Betty Pat, David W Johnson, Glenda C Gobe
Format: Article
Language:English
Published: Codon Publications 2018-05-01
Series:Journal of Renal and Hepatic Disorders
Online Access:https://jrenhep.com/index.php/jrenhep/article/view/30