Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs

Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs

Amyotrophic lateral sclerosis (ALS) is a progressive disease leading to the degeneration of motor neurons (MNs). Neuroinflammation is involved in the pathogenesis of ALS; however, interactions of specific immune cell types and MNs are not well studied. We recently found a shift toward T helper (Th)1...

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Bibliographic Details
Main Authors: Mengmeng Jin, Katja Akgün, Tjalf Ziemssen, Markus Kipp, Rene Günther, Andreas Hermann
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
induced pluripotent stem cells
motor neuron
multiple sclerosis
neurodegeneration
fused in sarcoma
Online Access:https://www.mdpi.com/1422-0067/22/15/8042

Internet

https://www.mdpi.com/1422-0067/22/15/8042

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