Intelligent Nanoparticles With pH-Sensitive Co-Delivery of Temozolomide and siEGFR to Ameliorate Glioma Therapy

Intelligent Nanoparticles With pH-Sensitive Co-Delivery of Temozolomide and siEGFR to Ameliorate Glioma Therapy

Glioblastoma (GBM) is one of the most lethal forms of human cancer, with very few long-term survivors. In addition to surgery, chemotherapy is still an important strategy. Unfortunately, GBM chemotherapy faces two main challenges: first, in GBM, epidermal growth factor receptor (EGFR) overexpression...

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Bibliographic Details
Main Authors: Zhen Wang, Yuyang Liu, Yong Xiao, Yandong Xie, Ran Wang, Yiding Zhang, Qi Zhou, Liang Liu, Shuo Sun, Hong Xiao, Yuanjie Zou, Kun Yang, Xiang Li, Mengjie Zhao, Yifang Hu, Hongyi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genetics
Subjects:
glioma
pH-responsive polymeric nanocarrier
synergistic therapy
TMZ
siEGFR
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.921051/full

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https://www.frontiersin.org/articles/10.3389/fgene.2022.921051/full

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