Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer

Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer

Abstract Knowing the activity of the mutational processes shaping a cancer genome may provide insight into tumorigenesis and personalized therapy. It is thus important to characterize the signatures of active mutational processes in patients from their patterns of single base substitutions. However,...

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Bibliographic Details
Main Authors: Damian Wojtowicz, Itay Sason, Xiaoqing Huang, Yoo-Ah Kim, Mark D. M. Leiserson, Teresa M. Przytycka, Roded Sharan
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Genome Medicine
Subjects:
Mutational process
Hidden Markov model
Mutation signature
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13073-019-0659-1

Internet

http://link.springer.com/article/10.1186/s13073-019-0659-1

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