Enhanced skin localization of doxycycline using microparticles and hydrogel: effect of oleic acid as penetration enhancer

Enhanced skin localization of doxycycline using microparticles and hydrogel: effect of oleic acid as penetration enhancer

One of the disadvantages of gel preparations is the poor ability to penetrate the skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based gel containing microparticle of doxycycline hyclate (DOX). Oleic acid (OA) was added into the gel formulation specifically to increase the penetr...

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Bibliographic Details
Main Authors: Aliyah Aliyah, Windy Winalda Oktaviana, Kadek Saka Dwipayanti, Arini Putri Erdiana, Rifka Nurul Utami, Andi Dian Permana
Format: Article
Language:English
Published: Universitas Ahmad Dahlan 2021-07-01
Series:Pharmaciana
Subjects:
oleic acid
gel
doxycycline microparticle
penetration enhancer
Online Access:http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/21044/pdf_195

Internet

http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/21044/pdf_195

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