Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

Metastasis-associated macrophages (MAMs) play pivotal roles in breast cancer metastasis by promoting extravasation and survival of metastasizing cancer cells. In a metastatic breast cancer mouse model, we previously reported that circulating classical monocytes (C-MOs) preferentially migrated into t...

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Bibliographic Details
Main Authors: Takanori Kitamura, Dahlia Doughty-Shenton, Luca Cassetta, Stamatina Fragkogianni, Demi Brownlie, Yu Kato, Neil Carragher, Jeffrey W. Pollard
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
breast cancer
metastasis
macrophage
myeloid-derived suppressor cell
immune suppression
CD8+ T cell
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.02004/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.02004/full

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