Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission

Summary: The lateral habenula (LHb) encodes aversive states, and its dysregulation is implicated in neuropsychiatric disorders, including depression. The endocannabinoid (eCB) system is a neuromodulatory signaling system that broadly serves to counteract the adverse effects of stress; however, CB1 r...

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Bibliographic Details
Main Authors: Nathan D. Winters, Veronika Kondev, Niharika Loomba, Eric Delpire, Brad A. Grueter, Sachin Patel
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723001705