Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Abstract The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes of disability, and current therapies...

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Bibliographic Details
Main Authors: Zuqiang Wang, Hangang Chen, Qiaoyan Tan, Junlan Huang, Siru Zhou, Fengtao Luo, Dali Zhang, Jing Yang, Can Li, Bo Chen, Xianding Sun, Liang Kuang, Wanling Jiang, Zhenhong Ni, Quan Wang, Shuai Chen, Xiaolan Du, Di Chen, Chuxia Deng, Liangjun Yin, Lin Chen, Yangli Xie
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-021-00165-x

Internet

https://doi.org/10.1038/s41413-021-00165-x

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