Novel digenic inheritance of PCDH15 and USH1G underlies profound non-syndromic hearing impairment

Novel digenic inheritance of PCDH15 and USH1G underlies profound non-syndromic hearing impairment

Abstract Background Digenic inheritance is the simplest model of oligenic disease. It can be observed when there is a strong epistatic interaction between two loci. For both syndromic and non-syndromic hearing impairment, several forms of digenic inheritance have been reported. Methods We performed...

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Bibliographic Details
Main Authors: Isabelle Schrauwen, Imen Chakchouk, Anushree Acharya, Khurram Liaqat, Irfanullah, University of Washington Center for Mendelian Genomics, Deborah A. Nickerson, Michael J. Bamshad, Khadim Shah, Wasim Ahmad, Suzanne M. Leal
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Medical Genetics
Subjects:
Digenic inheritance
Hearing impairment
Deafness
PCDH15
USH1G
Online Access:http://link.springer.com/article/10.1186/s12881-018-0618-5

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http://link.springer.com/article/10.1186/s12881-018-0618-5

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