HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy

HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy

Abstract Background Microglial activation-mediated neuroinflammation is one of the essential pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence suggests that high mobility group box-1 protein (HMGB1) plays a pivotal role in neuroinflammation and SAE, yet the mechanism...

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Bibliographic Details
Main Authors: Xiao-Yu Yin, Xiao-Hui Tang, Shi-Xu Wang, Yong-Chang Zhao, Min Jia, Jian-Jun Yang, Mu-Huo Ji, Jin-Chun Shen
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
Sepsis
High mobility group box-1 protein
Microglia
Synaptic pruning
Cognitive impairment
Online Access:https://doi.org/10.1186/s12974-023-02756-3

Internet

https://doi.org/10.1186/s12974-023-02756-3

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