Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells

Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells

T-cell lymphomas are aggressive lymphomas that often resist current therapy options or present with relapsed disease, making the development of more effective treatment regimens clinically important. Previously, we have shown that CD4 CAR can effectively target T-cell malignancies in preclinical stu...

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Bibliographic Details
Main Authors: Jia Feng, Haichan Xu, Andrew Cinquina, Zehua Wu, Wenli Zhang, Lihua Sun, Qi Chen, Lei Tian, Le Song, Kevin G. Pinz, Masayuki Wada, Xun Jiang, William M. Hanes, Yupo Ma, Hongyu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
T-cell lymphoma
hematopoietic cells
CAR T cells
CD4 CAR
IL15/IL15sushi
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.997482/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.997482/full

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