Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

New derivatives were synthesised by reaction of amino-containing aromatic sulphonamides with mono-, bi-, and tricyclic anhydrides. These sulphonamides were investigated as human carbonic anhydrases (hCAs, EC 4.2.1.1) I, II, IX, and XII inhibitors. hCA I was inhibited with inhibition constants (Kis)...

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Bibliographic Details
Main Authors: Kalyan K. Sethi, KM Abha Mishra, Saurabh M. Verma, Daniela Vullo, Fabrizio Carta, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
human carbonic anhydrase inhibitors
benzenesulphonamide
anhydride
docking
SAR
Online Access:https://www.mdpi.com/1424-8247/14/7/693

Internet

https://www.mdpi.com/1424-8247/14/7/693

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