Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors

Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors

Synthetic receptors provide a powerful experimental tool for generation of designer cells capable of monitoring the environment, sensing specific input signals, and executing diverse custom response programs. To advance the promise of cellular engineering, we have developed a class of chimeric recep...

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Bibliographic Details
Main Authors: Toni A. Baeumler, Ahmed Ashour Ahmed, Tudor A. Fulga
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
synthetic receptors
chimeric receptors
CRISPR
dCas9-VP64
split Cas9
GPCR
RTK
genome engineering
dCas9-synR
transcriptional programs
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731152X

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http://www.sciencedirect.com/science/article/pii/S221112471731152X

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