Polymeric Nanovectors Incorporated with Ganciclovir and HSV-<i>tk</i> Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy

Polymeric Nanovectors Incorporated with Ganciclovir and HSV-<i>tk</i> Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy

In the area of gene-directed enzyme prodrug therapy (GDEPT), using herpes simplex virus thymidine kinase (HSV-<i>tk</i>) paired with prodrug ganciclovir (GCV) for cancer treatment has been extensively studied. It is a process involved with two steps whereby the gene (HSV-<i>tk</...

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Bibliographic Details
Main Authors: Alicia J. Sawdon, Jun Zhang, Sarah Peng, Esmael M. Alyami, Ching-An Peng
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
polymeric micelles
ganciclovir
gene-directed enzyme prodrug therapy
prodrug
HT29 cells
HSV-<i>tk</i>
Online Access:https://www.mdpi.com/1420-3049/26/6/1759

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https://www.mdpi.com/1420-3049/26/6/1759

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