Transgenic Chlamydomonas Expressing Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channels to Assess the Effect of Agonists and Antagonists

Transgenic Chlamydomonas Expressing Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channels to Assess the Effect of Agonists and Antagonists

Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature. Since TRPA1 is associated with various disease symptoms and chemotherapeutic side effects, it is a frequent target of drug developmen...

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Bibliographic Details
Main Authors: Megumi Yoshida, Ryodai Yamamiya, Yuto Shimizu, Kenjiro Yoshimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
TRP channel
Chlamydomonas reinhardtii
TRPA1
phototaxis
bioassay
drug development
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.578955/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.578955/full

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