Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition.

Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition.

HMGB1 is a nuclear component involved in nucleosome stabilization and transcription regulation, but extracellularly it is able to serve as a potential late mediator of lethality. In the present study, we explored inflammation-promoting activity of HMGB1 and blockade of extracellular release of HMGB1...

Full description

Bibliographic Details
Main Authors: Noriyuki Kuroda, Kouji Inoue, Tadayuki Ikeda, Yaiko Hara, Kenjiro Wake, Tetsuji Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092884&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092884&type=printable

Similar Items