Clinical Development of Colony-Stimulating Factor 1 Receptor (CSF1R) Inhibitors
Macrophage infiltration has been identified as an independent poor prognostic factor for several cancers. Macrophages also orchestrate various tumor-promoting processes. This observation sparked an interest to therapeutically target these plastic innate immune cells. To date, blockade of colony-stim...
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| Format: | Article |
| Language: | English |
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Innovative Healthcare Institute
2021-05-01
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| Series: | Journal of Immunotherapy and Precision Oncology |
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| Online Access: | https://jipo.org/doi/pdf/10.36401/JIPO-20-32 |
| Summary: | Macrophage infiltration has been identified as an independent poor prognostic factor for several cancers. Macrophages also orchestrate various tumor-promoting processes. This observation sparked an interest to therapeutically target these plastic innate immune cells. To date, blockade of colony-stimulating factor 1 (CSF1) or its receptor represents one of the selective approaches to manipulate tumor-associated macrophages. In this review, I discuss the efficacy and safety of various CSF1 receptor tyrosine kinase inhibitors, anti–CSF1 receptor monoclonal antibodies, and anti-CSF1 monoclonal antibodies in clinical development for patients with cancer and highlight potential combination partners, mainly anti–program cell death protein 1 (PD-1) and program cell death protein ligand 1 (PD-L1) antibodies. |
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| ISSN: | 2666-2345 2590-017X |