E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity

Spheroids resemble features of tissues and serve as model systems to study cell–cell and cell–ECM interactions in non-adhesive three-dimensional environments. Although it is generally accepted that mature spheroids resemble tissue properties very well, no studies relate different phases in the spher...

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Bibliographic Details
Main Authors: I. Smyrek, B. Mathew, S. C. Fischer, S. M. Lissek, S. Becker, E. H. K. Stelzer
Format: Article
Language:English
Published: The Company of Biologists 2019-01-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/8/1/bio037051