Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline

Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline

Summary: Mitochondrial calcium overload contributes to neurodegenerative disease development and progression. We recently reported that loss of the mitochondrial sodium/calcium exchanger (NCLX), the primary mechanism of mCa2+ efflux, promotes mCa2+ overload, metabolic derangement, redox stress, and...

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Bibliographic Details
Main Authors: Pooja Jadiya, Henry M. Cohen, Devin W. Kolmetzky, Ashlesha A. Kadam, Dhanendra Tomar, John W. Elrod
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Behavioral neuroscience
Molecular neuroscience
Cellular neuroscience
Cognitive neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003735

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http://www.sciencedirect.com/science/article/pii/S2589004223003735

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