Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation

Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation

Metformin used as a first-line drug to treat Type 2 Diabetes Mellitus is transported via organic cation channels to soft tissues. Mutations in the SLC22A1 gene, such as Gly401Ser, Ser189Leu, and Arg206Cys, may affect the drug’s therapeutic effect on these patients. This study aims at proposing a pot...

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Bibliographic Details
Main Authors: Leydy Cano, Alejandro Soto-Ospina, Pedronel Araque, Maria Antonieta Caro-Gomez, Maria Victoria Parra-Marin, Gabriel Bedoya, Constanza Duque
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
pharmacogenetics
type 2 diabetes
metformin
structural biology
transport mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.587590/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.587590/full

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