Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling

Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling

Abstract Background Human mesenchymal stem cells (hMSCs) therapy has recently been considered a promising treatment for atopic dermatitis (AD) due to their immunomodulation and tissue regeneration ability. In our previous studies, we demonstrated that hMSCs alleviate allergic inflammation in murine...

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Bibliographic Details
Main Authors: Nari Shin, Namhee Jung, Seung-Eun Lee, Dasom Kong, Nam Gyo Kim, Myung Geun Kook, Hwanhee Park, Soon Won Choi, Seunghee Lee, Kyung-Sun Kang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Atopic dermatitis
Stem cell therapy
Combination therapy
Calcineurin inhibitor
NFAT signaling
COX2-PGE2 axis
Online Access:https://doi.org/10.1186/s13287-021-02547-8

Internet

https://doi.org/10.1186/s13287-021-02547-8

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