The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation

The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation

The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8th helix (H8), it is involved in early conformational changes following receptor activation as well as contacting the G protein β subunit. In class B1...

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Bibliographic Details
Main Authors: Ian Winfield, Kerry Barkan, Sarah Routledge, Nathan J. Robertson, Matthew Harris, Ali Jazayeri, John Simms, Christopher A. Reynolds, David R. Poyner, Graham Ladds
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Endocrinology
Subjects:
GPCRs
signaling bias
CLR
RAMPs
mutagenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.792912/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.792912/full

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