Copper-catalyzed multicomponent reaction of β-trifluoromethyl β-diazo esters enabling the synthesis of β-trifluoromethyl N,N-diacyl-β-amino esters

Copper-catalyzed multicomponent reaction of β-trifluoromethyl β-diazo esters enabling the synthesis of β-trifluoromethyl N,N-diacyl-β-amino esters

An efficient multicomponent reaction of newly designed β-trifluoromethyl β-diazo esters, acetonitrile, and carboxylic acids via an interrupted esterification process under copper-catalyzed conditions has been developed, which affords various unsymmetrical β-trifluoromethyl N,N-diacyl-β-amino esters...

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Bibliographic Details
Main Authors: Youlong Du, Haibo Mei, Ata Makarem, Ramin Javahershenas, Vadim A. Soloshonok, Jianlin Han
Format: Article
Language:English
Published: Beilstein-Institut 2024-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
β-carbonyl diazo
copper catalyst
fluoroalkyl diazo
mumm rearrangement
unsymmetrical β-diacylamino esters
Online Access:https://doi.org/10.3762/bjoc.20.21

Internet

https://doi.org/10.3762/bjoc.20.21

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