Engineered Fc-glycosylation switch to eliminate antibody effector function

Engineered Fc-glycosylation switch to eliminate antibody effector function

Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies where only antigen binding or neutralization would be id...

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Bibliographic Details
Main Authors: Qun Zhou, Julie Jaworski, Yanfeng Zhou, Delphine Valente, Joanne Cotton, Denise Honey, Ekaterina Boudanova, Jochen Beninga, Ercole Rao, Ronnie Wei, Christine Mauriac, Clark Pan, Anna Park, Huawei Qiu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Effector functions
silencing
antibody
glycosylation switch
Fc engineering
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1814583

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1814583

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