The Human Male Liver Is Predisposed to Inflammation Via Enhanced Myeloid Responses to Inflammatory Triggers

The Human Male Liver Is Predisposed to Inflammation Via Enhanced Myeloid Responses to Inflammatory Triggers

Background & AimMen have a higher prevalence of liver disease. Liver myeloid cells can regulate tissue inflammation, which drives progression of liver disease. We hypothesized that sex alters the responsiveness of liver myeloid cells, predisposing men to severe liver inflammation.MethodsLumi...

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Bibliographic Details
Main Authors: Adrian Kuipery, Deeqa Mahamed, Shirin Nkongolo, June Ann D’Angelo, Alexandra Johnson Valiente, Aman Mehrotra, William C. Chapman, Peter Horton, Ian McGilvray, Harry L. A. Janssen, Adam J. Gehring
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
sex
liver
monocytes
Hepatitis B virus
TLR signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.818612/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.818612/full

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