circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression

Abstract Background Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences. Recent studies have reported that cancer-associated chromosomal translocations could juxtapose distant complementary repetitive intron...

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Bibliographic Details
Main Authors: Wei Huang, Ke Fang, Tian-Qi Chen, Zhan-Cheng Zeng, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Zhen-Hua Chen, Qian-Qian Yang, Qi Pan, Xue-Qun Luo, Wen-Tao Wang, Yue-Qin Chen
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Hematology & Oncology
Subjects:
Circular RNA
MLL-AF4 fusion protein
Leukemia progression
Online Access:http://link.springer.com/article/10.1186/s13045-019-0800-z

Internet

http://link.springer.com/article/10.1186/s13045-019-0800-z

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