Isolation of Nocuolin A and Synthesis of New Oxadiazine Derivatives. Design, Synthesis, Molecular Docking, Apoptotic Evaluation, and Cathepsin B Inhibition

Isolation of Nocuolin A and Synthesis of New Oxadiazine Derivatives. Design, Synthesis, Molecular Docking, Apoptotic Evaluation, and Cathepsin B Inhibition

Nocuolin A (<b>1</b>), an oxadiazine, was isolated from the cyanobacterium <i>Nostoc</i> sp. Its chemical structure was elucidated using NMR and mass spectroscopic data. From this compound, two new oxadiazines, 3-[(6<i>R</i>)-5,6-dihydro-4,6-dipentyl-2<i>H&l...

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Bibliographic Details
Main Authors: Víctor Tena Pérez, Luis Apaza Ticona, Alfredo H. Cabanillas, Santiago Maderuelo Corral, Diego Fernando Rosero Valencia, Antera Martel Quintana, Montserrat Ortega Domenech, Ángel Rumbero Sánchez
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Marine Drugs
Subjects:
<i>Nostoc</i>
oxadiazines
anti-tumoural
cathepsins
Online Access:https://www.mdpi.com/1660-3397/21/5/284

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https://www.mdpi.com/1660-3397/21/5/284

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