Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit

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Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic reticulum (ER) via the ER Ca2+ ATPase pump. This...

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Bibliographic Details
Main Authors: Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
cellular physiology
molecular biology
cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007381

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http://www.sciencedirect.com/science/article/pii/S2589004223007381

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