Design, Assessment, and In Vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4+ T Lymphocytes

Design, Assessment, and In Vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4+ T Lymphocytes

Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T- cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communication, cellular proliferation, and immune synapse...

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Bibliographic Details
Main Authors: Brittany D Conroy, Tyler A Herek, Timothy D Shew, Matthew eLatner, Joshua J Larson, Laura eAllen, Paul H Davis, Tomas eHelikar, Christine E Cutucache
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Immunology
Subjects:
Computational Biology
Immunosuppression
Immunotherapy
caveolin-1
Adult T-cell leukemia
The Cell Collective
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00599/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00599/full

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