Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

A large number of different types of cancer have been shown to be associated with an abnormal metabolism of phosphatidylcholine (PC), the main component of eukaryotic cell membranes. Indeed, the overexpression of choline kinase α1 (ChoKα1), the enzyme that catalyses the bioconversion of choline to p...

Full description

Bibliographic Details
Main Authors: Pablo García-Molina, Alberto Sola-Leyva, Pilar M. Luque-Navarro, Alejandro Laso, Pablo Ríos-Marco, Antonio Ríos, Daniela Lanari, Archimede Torretta, Emilio Parisini, Luisa C. López-Cara, Carmen Marco, María P. Carrasco-Jiménez
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
cancer
lipid metabolism
choline kinase inhibitors
choline uptake
Online Access:https://www.mdpi.com/1999-4923/14/2/426

Internet

https://www.mdpi.com/1999-4923/14/2/426

Similar Items