Prolonged activation of cytomegalovirus early gene e1-promoter exclusively in neurons during infection of the developing cerebrum

Prolonged activation of cytomegalovirus early gene e1-promoter exclusively in neurons during infection of the developing cerebrum

Abstract The brain is the major target of congenital cytomegalovirus (CMV) infection. It is possible that neuron disorder in the developing brain is a critical factor in the development of neuropsychiatric diseases in later life. Previous studies using mouse model of murine CMV (MCMV) infection demo...

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Bibliographic Details
Main Authors: Isao Kosugi, Yoshifumi Arai, Satoshi Baba, Hideya Kawasaki, Toshihide Iwashita, Yoshihiro Tsutsui
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Acta Neuropathologica Communications
Subjects:
Cytomegalovirus
e1-promoter
Congenital infection
Persistent infection
Cerebral neuron
Neurodevelopmental disorder
Online Access:https://doi.org/10.1186/s40478-021-01139-0

Internet

https://doi.org/10.1186/s40478-021-01139-0

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