Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Abstract Background Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. Previous preclinical studies have revealed CGRP antagonistic effects on...

Full description

Bibliographic Details
Main Authors: Lena Ohlsson, Erik Kronvall, Jennifer Stratton, Lars Edvinsson
Format: Article
Language:English
Published: BMC 2018-08-01
Series:The Journal of Headache and Pain
Subjects:
Online Access:http://link.springer.com/article/10.1186/s10194-018-0905-8