Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

Abstract Background Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. Previous preclinical studies have revealed CGRP antagonistic effects on...

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Bibliographic Details
Main Authors: Lena Ohlsson, Erik Kronvall, Jennifer Stratton, Lars Edvinsson
Format: Article
Language:English
Published: BMC 2018-08-01
Series:The Journal of Headache and Pain
Subjects:
CGRP
CGRP receptor antagonist
Antibody
Fremanezumab
Human vessels
Online Access:http://link.springer.com/article/10.1186/s10194-018-0905-8

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