Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication

MicroRNA have been demonstrated to be deregulated in multiple myeloma. We have previously reported that miR-214 is down-regulated in multiple myeloma compared to in normal plasma cells. The functional role of miR-214 in myeloma pathogenesis was explored by transfecting myeloma cell lines with synthe...

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Bibliographic Details
Main Authors: Irena Misiewicz-Krzeminska, María E. Sarasquete, Dalia Quwaider, Patryk Krzeminski, Fany V. Ticona, Teresa Paíno, Manuel Delgado, Andreia Aires, Enrique M. Ocio, Ramón García-Sanz, Jesús F. San Miguel, Norma C. Gutiérrez
Format: Article
Language:English
Published: Ferrata Storti Foundation 2013-04-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/6636