EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment

EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment

Abstract Background Glioblastoma multiforme (GBM) induces tumor immunosuppression through interacting with tumor-infiltrating microglia or macrophages (TAMs) with an unclear pathogenesis. Enhancer of zeste homolog 2 (EZH2) is abundant in GBM samples and cell lines and is involved in GBM proliferatio...

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Bibliographic Details
Main Authors: Yatao Yin, Shuwei Qiu, Xiangpen Li, Bo Huang, Yun Xu, Ying Peng
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Neuroinflammation
Subjects:
Enhancer of zeste homolog 2 (EZH2)
Glioblastoma
Microglia
Polarization
Online Access:http://link.springer.com/article/10.1186/s12974-017-0993-4

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http://link.springer.com/article/10.1186/s12974-017-0993-4

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