Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Abstract Dysfunction of parvalbumin (PV) neurons is closely involved in depression, however, the detailed mechanism remains unclear. Based on the previous finding that multiple endocrine neoplasia type 1 (Protein: Menin; Gene: Men1) mutation (G503D) is associated with a higher risk of depression, a...

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Bibliographic Details
Main Authors: Lige Leng, Kai Zhuang, Hui Lin, Jinjun Ding, Shangchen Yang, Ziqi Yuan, Changquan Huang, Guimiao Chen, Zhenlei Chen, Mengdan Wang, Han Wang, Hao Sun, Huifang Li, He Chang, Zhenyi Chen, Qi Xu, Tifei Yuan, Jie Zhang
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Advanced Science
Subjects:
depression
epigenetics
ketamine
menin
parvalbumin
Online Access:https://doi.org/10.1002/advs.202305659

Internet

https://doi.org/10.1002/advs.202305659

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