Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice

Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice

Abstract Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are caused by mutations to the Dysferlin and Dystrophin genes, respectively. We have recently demonstrated in typically mild dysferlin- and dystrophin-deficient mouse models that increased plasma cholesterol levels s...

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Bibliographic Details
Main Authors: Zoe White, Zeren Sun, Elodie Sauge, Dan Cox, Graham Donen, Dmitri Pechkovsky, Volker Straub, Gordon A. Francis, Pascal Bernatchez
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Skeletal Muscle
Subjects:
Dysferlin
Dyslipidemia
Simvastatin
Cholesterol
Online Access:https://doi.org/10.1186/s13395-022-00308-6

Internet

https://doi.org/10.1186/s13395-022-00308-6

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