In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice.

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice.

The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Abeta and tau in the wild-type and Tg2576 mouse brain using cycloheximide to block protein synthesis. In...

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Bibliographic Details
Main Authors: Jose Morales-Corraliza, Matthew J Mazzella, Jason D Berger, Nicole S Diaz, Jennifer H K Choi, Efrat Levy, Yasuji Matsuoka, Emmanuel Planel, Paul M Mathews
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2741602?pdf=render

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http://europepmc.org/articles/PMC2741602?pdf=render

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