Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy

Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy

Abstract Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell proliferation, and inhibition of PPM1D expression in DIPG cells with PPM1D mutation effectively reduces the proliferatio...

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Bibliographic Details
Main Authors: Shaobo Shan, Junge Chen, Yu Sun, Yongchao Wang, Bozhang Xia, Hong Tan, Changcun Pan, Guocan Gu, Jie Zhong, Guangchao Qing, Yuxuan Zhang, Jinjin Wang, Yufei Wang, Yi Wang, Pengcheng Zuo, Cheng Xu, Fangzhou Li, Weisheng Guo, Lijun Xu, Meiwan Chen, Yubo Fan, Liwei Zhang, Xing‐Jie Liang
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
blood–brain barrier
diffuse intrinsic pontine glioma
macrophage exosomes
panobinostat
siRNA blood‐brain barrier
Online Access:https://doi.org/10.1002/advs.202200353

Internet

https://doi.org/10.1002/advs.202200353

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