Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.

Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.

The adhesion molecule and co-receptor of receptor tyrosine kinases, CD44, is expressed in all cells of the immune system, but also in numerous non-immune cells. CD44 plays roles in the cellular response to different pathogens. The molecular actions of CD44 during these processes are by and large sti...

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Bibliographic Details
Main Authors: Kristin Schultz, Christina Grieger Lindner, Yong Li, Pavel Urbánek, Anne Ruschel, Kerstin Minnich, Dunja Bruder, Marcus Gereke, Antonio Sechi, Peter Herrlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207358

Internet

https://doi.org/10.1371/journal.pone.0207358

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