Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits

Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits

Amyloid beta 1-42 (Aβ42) aggregates acutely impair hippocampal long-term potentiation (LTP) of synaptic transmission, and 17β-estradiol is crucial for hippocampal LTP. We tested whether boosting the synthesis of neural-derived 17β-estradiol (nE2) saves hippocampal LTP by the neurotoxic action of Aβ4...

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Bibliographic Details
Main Authors: Laura Bellingacci, Jacopo Canonichesi, Miriam Sciaccaluga, Alfredo Megaro, Petra Mazzocchetti, Michela Di Mauro, Cinzia Costa, Massimiliano Di Filippo, Vito Enrico Pettorossi, Alessandro Tozzi
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
17β-estradiol
P450-aromatase
5α-reductase
LTP
synaptic plasticity
estrogen
Online Access:https://www.mdpi.com/1422-0067/25/3/1377

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https://www.mdpi.com/1422-0067/25/3/1377

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