The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

Abstract Background Sodium-glucose cotransporter (SGLT)2 inhibitors have displayed beneficial effects on the cardiovascular system in diabetes mellitus (DM) patients. As most clinical trials were performed in Type 2 DM, their effects in Type 1 DM have not been established. Objective To evaluate the...

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Main Authors: Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Diabetology & Metabolic Syndrome
Subjects:
SGLT2 inhibitors
Streptozotocin
Papillary muscle
Ventricular function
Myocardial metabolomics
Echocardiogram
Online Access:https://doi.org/10.1186/s13098-023-01196-6

Internet

https://doi.org/10.1186/s13098-023-01196-6

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