IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy

IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy

Abstract Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located within oligodendroglia. Neuroinflammation, demyelination, and neurodegeneration are correlated with areas of glia cytoplasmic inclusions (GCI)...

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Bibliographic Details
Main Authors: Nicole J. Corbin-Stein, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple system atrophy
Neuroinflammation
Alpha-synuclein
T cells
Interferon gamma
Online Access:https://doi.org/10.1186/s40478-023-01710-x

Internet

https://doi.org/10.1186/s40478-023-01710-x

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