NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer

NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer

5-aza-2′,2′-difluorodeoxycytidine (NUC013) has been shown to be significantly safer and more effective than decitabine in xenograft models of human leukemia and colon cancer. However, it suffers from a similar short half-life as other DNA methyltransferase inhibitors with a 5-aza...

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Bibliographic Details
Main Authors: Richard Daifuku, Sheila Grimes, Murray Stackhouse
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Pharmaceuticals
Subjects:
5-azacytidine
cancer
decitabine
epigenetics
DNA methyltransferase
natural killer cells
NUC013
NUC041
nucleoside
p53
ribonucleotide reductase
Online Access:http://www.mdpi.com/1424-8247/11/2/36

Internet

http://www.mdpi.com/1424-8247/11/2/36

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