The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program

The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program

Breast cancer is the leading cause of cancer death in the female population, despite advances in diagnosis and treatment. The highly heterogeneous nature of the disease represents a major obstacle to successful therapy and results in a significant number of patients developing drug resistance and, e...

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Bibliographic Details
Main Authors: John Verigos, Panagiotis Karakaidos, Dimitris Kordias, Alexandra Papoudou-Bai, Zoi Evangelou, Haralampos V. Harissis, Apostolos Klinakis, Angeliki Magklara
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
breast cancer stem cells
tumor heterogeneity
therapy resistance
combination therapy
self-renewal
tumor initiation
lysine-specific demethylase 1
kdm1a
Online Access:https://www.mdpi.com/2072-6694/11/10/1585

Internet

https://www.mdpi.com/2072-6694/11/10/1585

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