FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion

FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion

Abstract Background Traumatic spinal cord injury (SCI)-induced neuroinflammation results in secondary neurological destruction and functional disorder. Previous findings showed that microglial pyroptosis plays a crucial role in neuroinflammation. Thus, it is necessary to conduct a comprehensive inve...

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Main Authors: Mingjie Xia, Xinyu Li, Suhui Ye, Qinyang Zhang, Tianyu Zhao, Rulin Li, Yanan Zhang, Minghan Xian, Tianqi Li, Haijun Li, Xin Hong, Shengnai Zheng, Zhanyang Qian, Lei Yang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Cell & Bioscience
Subjects:
Spinal cord injury
FANCC
NLRP3
Microglia
Pyroptosis
Neuronal apoptosis
Online Access:https://doi.org/10.1186/s13578-022-00816-4

Internet

https://doi.org/10.1186/s13578-022-00816-4

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