The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy
Picornaviruses can escape infected cells via packaging in extracellular vesicles (EVs). Here, van der Grein et al. show that the non-structural Leader protein of encephalomyocarditis virus (EMCV) promotes the release of EV-enclosed virus particles and provide evidence for a role of secretory autopha...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31181-y |
| _version_ | 1818250277375967232 |
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| author | Susanne G. van der Grein Kyra A. Y. Defourny Huib H. Rabouw Soenita S. Goerdayal Martijn J. C. van Herwijnen Richard W. Wubbolts Maarten Altelaar Frank J. M. van Kuppeveld Esther N. M. Nolte-‘t Hoen |
| author_facet | Susanne G. van der Grein Kyra A. Y. Defourny Huib H. Rabouw Soenita S. Goerdayal Martijn J. C. van Herwijnen Richard W. Wubbolts Maarten Altelaar Frank J. M. van Kuppeveld Esther N. M. Nolte-‘t Hoen |
| author_sort | Susanne G. van der Grein |
| collection | DOAJ |
| description | Picornaviruses can escape infected cells via packaging in extracellular vesicles (EVs). Here, van der Grein et al. show that the non-structural Leader protein of encephalomyocarditis virus (EMCV) promotes the release of EV-enclosed virus particles and provide evidence for a role of secretory autophagy in this process. |
| first_indexed | 2024-12-12T15:49:50Z |
| format | Article |
| id | doaj.art-532460d12a0d4231b60592e26e89f23d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T15:49:50Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-532460d12a0d4231b60592e26e89f23d2022-12-22T00:19:40ZengNature PortfolioNature Communications2041-17232022-06-0113111410.1038/s41467-022-31181-yThe encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagySusanne G. van der Grein0Kyra A. Y. Defourny1Huib H. Rabouw2Soenita S. Goerdayal3Martijn J. C. van Herwijnen4Richard W. Wubbolts5Maarten Altelaar6Frank J. M. van Kuppeveld7Esther N. M. Nolte-‘t Hoen8Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDivision of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityVirology Section, Division Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityDivision of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDivision of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityVirology Section, Division Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDivision of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityPicornaviruses can escape infected cells via packaging in extracellular vesicles (EVs). Here, van der Grein et al. show that the non-structural Leader protein of encephalomyocarditis virus (EMCV) promotes the release of EV-enclosed virus particles and provide evidence for a role of secretory autophagy in this process.https://doi.org/10.1038/s41467-022-31181-y |
| spellingShingle | Susanne G. van der Grein Kyra A. Y. Defourny Huib H. Rabouw Soenita S. Goerdayal Martijn J. C. van Herwijnen Richard W. Wubbolts Maarten Altelaar Frank J. M. van Kuppeveld Esther N. M. Nolte-‘t Hoen The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy Nature Communications |
| title | The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy |
| title_full | The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy |
| title_fullStr | The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy |
| title_full_unstemmed | The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy |
| title_short | The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy |
| title_sort | encephalomyocarditis virus leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy |
| url | https://doi.org/10.1038/s41467-022-31181-y |
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