Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse

Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse

Abstract Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α. This study aims to elucidate the potential roles of Prok2 in OA. Methods Prok2 expre...

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Bibliographic Details
Main Authors: Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim, Jang-Soo Chun
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Arthritis Research & Therapy
Subjects:
Prokineticin
Chondrocytes
Osteoarthritis
Matrix-degrading enzymes
Mechanical allodynia
Biomarker
Online Access:https://doi.org/10.1186/s13075-023-03206-4

Internet

https://doi.org/10.1186/s13075-023-03206-4

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