Targeted Disruption of Melanin Biosynthesis Genes in the Human Pathogenic Fungus Lomentospora prolificans and Its Consequences for Pathogen Survival

Targeted Disruption of Melanin Biosynthesis Genes in the Human Pathogenic Fungus Lomentospora prolificans and Its Consequences for Pathogen Survival

The dematiaceous (melanised) fungus Lomentospora (Scedosporium) prolificans is a life-threatening opportunistic pathogen of immunocompromised humans, resistant to anti-fungal drugs. Melanin has been shown to protect human pathogenic fungi against antifungal drugs, oxidative killing and environmental...

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Bibliographic Details
Main Authors: Ayat Al-Laaeiby, Michael J. Kershaw, Tina J. Penn, Christopher R. Thornton
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
Lomentospora
melanin
fungus
pathogen
scytalone dehydratase
polyketide synthase
tetrahydroxynaphthalene reductase
gene
Online Access:http://www.mdpi.com/1422-0067/17/4/444

Internet

http://www.mdpi.com/1422-0067/17/4/444

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