Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are ubiquitin-like proteins recruited to autophagosome membranes by lipidation at the C-terminus. ATG8s recruit substrates, such as p62,...

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Bibliographic Details
Main Authors: Wenxin Zhang, Taki Nishimura, Deepanshi Gahlot, Chieko Saito, Colin Davis, Harold BJ Jefferies, Anne Schreiber, Lipi Thukral, Sharon A Tooze
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
autophagy
cis-membrane association
membrane expansion
autophagosome size
real-time lipidation assay
atomistic MD simulation
Online Access:https://elifesciences.org/articles/89185

Internet

https://elifesciences.org/articles/89185

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